Improving DNA array data quality by minimising 'neighbourhood' effects
نویسندگان
چکیده
منابع مشابه
Improving DNA array data quality by minimising 'neighbourhood' effects.
Gene expression studies using cDNA arrays require robust and sensitive detection methods. Being extremely sensitive, radioactive detection suffers from the influence of signals positioned in each other's vicinity, the 'neighbourhood' effect. This limits the gene density of arrays and the quality of the results obtained. We have investigated the quantitative influence of different parameters on ...
متن کاملProcessing and quality control of DNA array hybridization data
MOTIVATION The technology of hybridization to DNA arrays is used to obtain the expression levels of many different genes simultaneously. It enables searching for genes that are expressed specifically under certain conditions. However, the technology produces large amounts of data demanding computational methods for their analysis. It is necessary to find ways to compare data from different expe...
متن کاملImproving Mining Quality by Exploiting Data Dependency
The usefulness of the results produced by data mining methods can be critically impaired by several factors such as (1) low quality of data, including errors due to contamination, or incompleteness due to limited bandwidth for data acquisition, and (2) inadequacy of the data model for capturing complex probabilistic relationships in data. Fortunately, a wide spectrum of applications exhibit str...
متن کاملTowards Improving Data Quality
This paper is based on the notion of data quality. It includes correctness, completeness and minimality for which a notational framework is shown. In long living databases the maintenance of data quality is a rst order issue. This paper shows that even well designed and implemented information systems cannot guarantee correct data in any circumstances. It is shown that in any such system data q...
متن کاملSorting out Neighbourhood Effects Using Sibling Data
IZA DP No. 11178 NOVEMBER 2017 Sorting out Neighbourhood Effects Using Sibling Data Previous research has reported evidence of intergenerational transmission of both neighbourhood status and social and economic outcomes later in life; parents influence where their children live as adults and how well they do later in life in terms of their income. However, interactions between the individual, t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2002
ISSN: 1362-4962
DOI: 10.1093/nar/gnf127